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A. James Clark School of Engineering Home
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Fischell Department of Bioengineering

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Department of Orthopaedics
Univ of Maryland, Baltimore
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Graduate Program in
Biological Sciences,
Physiological Systems

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Department of Mechanical Engineering
 


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Graduate Research Assistant

Poonam came to the University of Maryland in the fall of 2012, after finishing her Bachelor's in Biomedical Engineering from Drexel University. She joined the lab in Spring of 2013 and has been working on analyzing how the stem cell mechanobiology, specifically selective downregulation of cytoskeletal elements in human mesenchymal stem cells. The goal of this project is to better understand how the cytoskeleton is involved in mechanotransduction in stem cells and during chondrogenesis. Outside of the lab, she is an officer in the Bioengineering Graduate Student Society.

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Education

  • B.S. in Biomedical Engineering, Concentration in Biomaterials and Tissue Engineering, Drexel University (2012)

Research Interests

  • Mechanobiology of Stem Cells
  • Stem Cell Therapies
  • Chondrogenesis
  • Tissue Engineering and Biomaterials

Publications

  • Sharma, P., Bolten, Z.T., Wagner, D.R., Hsieh, A. H. Deformability of human mesenchymal stem cells is dependent on vimentin intermediate filaments. Ann Biomed Eng. 2017 May;45(5):1365-1374. doi: 10.1007/s10439-016-1787-z. Epub 2017 Jan 13.
  • Sharma, P., Twomey, J. D., Patkin, M., Hsieh, A. H. Layered Alginate Constructs: A Platform for Co-culture of Heterogeneous Cell Populations. J. Vis. Exp. (114), e54380, doi:10.3791/54380 (2016).

Posters/Presentations

  • Sharma, P, Wagner, DR, Hsieh, AH. Vimentin Knockdown Impairs Neo-Cartilage Formation in Human Mesenchymal Stem Cell Pellet Cultures. Orthopaedic Research Society. Poster. San Diego, CA, March 19-22, 2017.
  • Bolten, Z, Sharma, P, Luna, C, Wagner, DR, Hsieh, AH. Vimentin Upregulation in Human Mesenchymal Stem Cells Increases Cell Traction. Orthopaedic Research Society. Poster. San Diego, CA, March 19-22, 2017.
  • Sharma, P, Wagner, DR, Hsieh, AH. Vimentin Intermediate filaments alter substrate-specificity of adhesion and spreading in hMSCs. Cellular and Molecular Bioengineering. Poster. Big Island, HI, January 3-7, 2017.
  • Peesay, T, Luna, C, Sharma, P, Hsieh, AH. Vimentin Affects Cellular Protrusion Formation in hMSCs During Transwell Migration. Biomedical Engineering Society. Poster. Minneapolis, MN, October 5-8, 2016.
  • Sharma, P, Bolten, Z, Wagner, DR, Hsieh, AH. Vimentin Knockdown Alters Cytoskeletal Response to Deformation in Mesenchymal Stem Cells. Poster. Orthopaedic Research Society, Orlando, Fl, March 5-10, 2016.
  • Sharma, P, Bolten, Z, Wagner, DR, Hsieh, AH. Mesenchymal Stem Cell Deformability is Dependent on Vimentin Intermediate Filaments. Poster. Cellular and Molecular Bioengineering, New Orleans, LA, January 6-10, 2016.
  • Sharma, P, Bolten, Z, Wagner, DR, Hsieh, AH. Vimentin Knockdown in Mesenchymal Stem Cells Modifies Cell Deformability. Oral Presentation. Biomedical Engineering Society, Tampa, FL, October 7-10, 2015.
  • Sharma, P, Patkin, M., Hsieh, AH. Layered Alginate Constructs: Platform Development for Co-cultures of Heterogenous Cell Populations. Poster 1138. Orthopaedic Research Society, Las Vegas, NV, March 27-31, 2015.
  • Sharma, P, Bolten, Z, Wagner, DR, Hsieh, AH. Cytoskeletal Response to Vimentin Knockdown and Disruption in Human Mesenchymal Stem Cells. Poster. Maryland Research Fund Stem Cell Symposium, Silver Spring, MD, December, 2014.

Awards

  • RoosterBio Travel Award, February 2017, awarded by RoosterBio, Inc
  • Jacob K. Goldhaber Travel Grant, October 2016, awarded by University of Maryland Graduate School
  • National Science Foundation Graduate Research Fellowship, April 2014 - Honorable Mention, awarded by NSF GRFP
 
   
 

 

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